The 29E.2A3 monoclonal antibody reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. The 29E.2A3 antibody has been shown to block the binding of PD-1-Ig to PD-L1.

产品名称:InVivoMab anti-human PD-L1 (B7-H1)

反应种属:human

宿主来源:mouse

实验应用:in vitro PD-L1 blockade, Functional assays, Immunohistochemistry (frozen), Flow cytometry

同种型:IgG2b, κ

免疫原:Full length human PD-L1

克隆性:Monoclonal

克隆号:29E.2A3

产品浓度:Lot specific,typically between 4-11 mg/ml

保存温度:Undiluted at 4°C in the dark

运输温度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

预期分子量:150 kDa

产品形式:液体

有效期:One year from the date of receipt if stored as recommended

产地:美国

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