The 53-5.8 monoclonal antibody reacts with mouse CD8β also known as Lyt 3.2. The CD8 antigen is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to class I MHC molecules displayed by antigen presenting cells (APC). CD8 is primarily expressed on the surface of cytotoxic T cells, but can also be found on thymocytes, natural killer cells, and some dendritic cell subsets. CD8 most commonly exists as a heterodimer composed of one CD8α and one CD8β chain however, it can also exist as a homodimer composed of two CD8α chains. Both the CD8α and CD8β chains share significant homology to immunoglobulin variable light chains. The molecular weight of each CD8 chain is approximately 34 kDa. The 53-5.8 antibody has been shown to deplete CD8+ T cells completely but not deplete CD8+ CD11c+ dendritic cells when used in vivo.

产品名称:InVivoMab anti-mouse CD8β (Lyt 3.2)

反应种属:mouse

宿主来源:rat

实验应用:in vivo CD8+ T cell depletion, in vitro CD8 blockade, Immunofluorescence

同种型:IgG1, κ

免疫原:Mouse thymus or spleen

克隆性:Monoclonal

克隆号:53-5.8

产品浓度:Lot specific,typically between 4-11 mg/ml

保存温度:Undiluted at 4°C in the dark

运输温度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

预期分子量:150 kDa

产品形式:液体

有效期:One year from the date of receipt if stored as recommended

产地:美国

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