The 145-2C11 monoclonal antibody reacts with mouse CD3ε, a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. CD3ε is one of five polypeptide chains that combine to form the TCR complex. CD3ε is expressed on T lymphocytes, NK-T cells, and to varying degrees on developing thymocytes. CD3 plays roles in TCR signaling, T lymphocyte activation, and antigen recognition. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death. Activation of resting T cells in vivo results in cytokine release and subsequent toxicity caused by Ab-mediated cross-linking of T cells and Fcγ receptor (FcR)-bearing cells. For this reason, the non-FcR-binding 145-2C11 f(ab')2 fragments are more commonly used for in vivo applications.  The 145-2C11 antibody has been reported to block the binding of the 17A2 antibody to CD3ε+ T lymphocytes.

产品名称:InVivoMab anti-mouse CD3ε

反应种属:mouse

宿主来源:Armenian hamster

实验应用:in vivo T cell depletion, in vitro T cell stimulatioN/Activation, Immunofluorescence, Flow cytometry

同种型:IgG

免疫原:Mouse BM10-37 cytotoxic T cells

克隆性:Monoclonal

克隆号:145-2C11

产品浓度:Lot specific,typically between 4-11 mg/ml

保存温度:Undiluted at 4°C in the dark

运输温度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

预期分子量:150 kDa

产品形式:液体

有效期:One year from the date of receipt if stored as recommended

产地:美国

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