The LOB12.3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. 4-1BB is a 39 kDa transmembrane protein expressed by T lymphocytes, NK cells, dendritic cells, granulocytes, and mast cells. Upon binding its ligand 4-1BBL, 4-1BB provides costimulatory signals to both CD4 and CD8 T cells through the activation of NF- κB, c-Jun and p38 downstream pathways. The importance of the 4-1BB pathway has been underscored in a number of diseases, including cancer. Agonistic anti-4-1BB antibodies have been reported to induce T cell mediated antitumor immunity. The LOB12.3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growth in vivo when administered in combination with immune checkpoint inhibitors.

产品名称:InVivoMab anti-mouse 4-1BB (CD137)

反应种属:mouse

宿主来源:rat

实验应用:in vivo activation of 4-1BB

同种型:IgG2a

免疫原:Mouse CD137 human Fc fusion protein

克隆性:Monoclonal

克隆号:LOB12.3

产品浓度:Lot specific,typically between 4-11 mg/ml

保存温度:Undiluted at 4°C in the dark

运输温度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

预期分子量:150 kDa

产品形式:液体

有效期:One year from the date of receipt if stored as recommended

产地:美国

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