The MIAP410 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is a receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis. CD47 Is has been found to be overexpressed in many different tumor cells. Because of this, anti-CD47 monoclonal antibodies have been proposed and studied as a therapeutic treatment for human cancers. The MIAP410 antibody has been shown to neutralize CD47 in vivo and in vitro.

产品名称:InVivoMab anti-human/mouse/rat CD47

反应种属:human/mouse/rat

宿主来源:mouse

实验应用:in vivo CD47 blockade, in vitro CD47 blockade, Immunofluorescence

同种型:IgG1, κ

免疫原:purified human placental CD47

克隆性:Monoclonal

克隆号:MIAP410

产品浓度:Lot specific,typically between 4-11 mg/ml

保存温度:Undiluted at 4°C in the dark

运输温度:Ship with adequate amount of blue ice to ensure the product remains at 4°C for the duration of transit

预期分子量:150 kDa

产品形式:液体

有效期:One year from the date of receipt if stored as recommended

产地:美国

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